Wills Lab

How are memories encoded in the brain? What makes some memories fade and other last a lifetime? Why can we not retain our memories of early childhood? In our lab, we investigate these questions by looking at the activity of neural circuits in the hippocampus and connected brain regions during memory formation and retrieval.

The hippocampus creates episodic memories – defined as memories of events, as well as where and when they occurred. Hippocampus neurons create neural ‘maps’ of places that animals visit, by tuning their firing to an animal’s current position or orientation in space (examples of these neurons include place cells, grid cells and head direction cells). These neural maps are the basis for remembering where events occurred, are necessary if we wish to navigate back to places we remember. Our research aims to understand how these neural maps support memories, with a special interest in how they emerge during post-natal development. To address these problems, we use cutting-edge technologies to both visualise and manipulate neural circuits during behaviour (tetrode recording, neuropixels silicon probes, 2-photon microscopy and opto- and chemo-genetics).